Recent research underscores that even the absence of detectable life on exoplanets can yield crucial insights into the prevalence of life in the universe.
Key Points at a Glance
- A study led by ETH Zurich and the SETI Institute explores the implications of not detecting biosignatures on exoplanets.
- Analyzing 40–80 planets without finding signs of life could indicate that fewer than 10–20% of similar planets harbor life.
- These findings emphasize the importance of understanding null results in astrobiological research.
- Upcoming missions like NASA’s Habitable Worlds Observatory (HWO) and the European Large Interferometer for Exoplanets (LIFE) are poised to study numerous Earth-like planets for biosignatures.
- Accurate interpretation of data from these missions requires careful consideration of observational uncertainties and biases.
The quest to discover life beyond Earth has primarily focused on detecting biosignatures—indicators such as water vapor, oxygen, or methane—in the atmospheres of exoplanets. However, a recent study led by researchers from ETH Zurich, including Dr. Daniel Angerhausen of the SETI Institute, highlights the importance of null results—instances where no signs of life are found—and their potential to inform our understanding of life’s distribution in the cosmos.
Published on April 7, 2025, this study employs advanced statistical modeling to assess how the absence of detectable biosignatures can shape our perceptions of life’s rarity or commonality in the universe. The researchers propose that examining between 40 and 80 exoplanets without detecting signs of life could lead to a confident conclusion that fewer than 10–20% of similar planets host life. This approach allows scientists to establish meaningful upper limits on the prevalence of life, a feat previously unattainable.

Dr. Angerhausen emphasizes the value of such findings: “Even a single positive detection would change everything—but until then, we need to make sure we’re learning as much as possible from what we don’t find.” This perspective underscores the necessity of interpreting null results not as failures but as critical data points that refine our understanding of life’s distribution.
The study’s implications are particularly relevant for forthcoming space missions designed to probe exoplanetary atmospheres for biosignatures. NASA’s Habitable Worlds Observatory (HWO) and the European-led Large Interferometer for Exoplanets (LIFE) are set to observe dozens of Earth-like planets. The research suggests that the sample sizes targeted by these missions are sufficient to draw significant conclusions about habitability and the potential for life in our galactic neighborhood.
However, the study also highlights the need for meticulous consideration of observational uncertainties and biases. Factors such as false negatives—where biosignatures are present but undetected—can significantly influence interpretations. Therefore, developing frameworks to quantify and account for these uncertainties is essential to ensure statistically meaningful results.
In conclusion, while the detection of extraterrestrial life remains a paramount goal, this research illuminates the profound insights that can be gleaned from null results. By systematically analyzing the absence of biosignatures, scientists can better understand the factors influencing life’s emergence and distribution, ultimately contributing to a more comprehensive picture of our universe.
Source: SETI Institute